The Win Ratio, introduced in 2012, analyzes composite endpoints based on clinical priorities . It prioritizes clinically significant events by calculating the total number of winners divided by losers.
💡 Key Features of the Win Ratio
– Considers relative priorities of individual components in composite endpoints.
– Combines qualitative and quantitative outcomes for a more informative analysis.
– Includes patient-centered outcomes, enhancing clinical relevance .
📊 Internal Implementation and Interpretation
Patients in treatment and control groups are paired based on risk profiles, and the Win Ratio is calculated for each pair. Ratios greater than 1 indicate a higher likelihood of favorable outcomes in the treatment group .
💻 Implementation using SAS and R
Researchers use statistical frameworks for “time to event” data, testing union hypotheses for hazard rates . SAS and R facilitate straightforward implementation [9.2].
📖 Real Studies with Protocols and SAPs
The Win Ratio has been applied successfully in cardiovascular trials like NCT05411991 [10.1], NCT03888066 [10.2], and NCT01626079 [10.3], providing valuable insights for treatment comparisons.
 Pocock, S. J., et al. (2012). https://lnkd.in/gwN7ciX8
 Pocock, S. J., et al. (2020). https://lnkd.in/gBdHDNzb
 Ferreira, J. P., et al. (2021). https://lnkd.in/gnRt24Wy
 Ipek, M., et al. (2014). https://lnkd.in/gDWSuVMP
 Lachin, J. M. (2019). https://lnkd.in/g-QXKsXv
 Lachin, J. M., et al. (2022). https://lnkd.in/gp8x9Cd8
 Lachin, J. M., et al. (2019). https://lnkd.in/g3xnd_Wq
 Bebu, I., et al. (2015). https://lnkd.in/g5AqEQse
[9.1] Bebu, I., et al. (2015). https://lnkd.in/g9cUvrcE
[9.2] WinRatio package for R (Version 1.0.0) [Software]. https://lnkd.in/gcgmtxqF
[10.1] clinicaltrials.gov; NCT05411991. https://lnkd.in/gxqe5BVW
[10.2] clinicaltrials.gov; NCT03888066. https://lnkd.in/gvbtNqyP
[10.3] clinicaltrials.gov; (n.d.). NCT01626079. https://lnkd.in/gn_FyQde